Monday, 5 February 2018

WHAT ARE THE RISK FACTORS FOR PLEURAL MESOTHELIOMA?


The most significant risk factor for pleural mesothelioma is long-term exposure to asbestos – a history of exposure has been reported in over 90% of cases.3 Asbestos is a fibrous material that is resistant to fire, resulting in its use as insulation and in fire safety products.1 Different types of asbestos fibre include serpentine (long and curvy) and amphibole (straight and needle-like). Due to their shape, serpentine fibres are more easily cleared from the lungs. Crocidolite fibres (a subtype of amphibole fibres) are most commonly associated with pleural mesothelioma.1
Although asbestos exposure is the major risk for developing mesothelioma, other associated causes can include germline mutation in the BRCA1 associated protein 1 (BAP1) gene9 exposure to a volcanic mineral called erionite. Erionite is a fibrous material that belongs to a group of minerals called zeolites, which are chemically related to asbestos.1,3
In rare cases, individuals can also develop pleural mesothelioma without asbestos or erionite exposure. These cases are usually classified into:3
 Idiopathic mesothelioma, a sporadic malignancy occurring in childhood or adolescence
 Spontaneous mesothelioma, a spontaneous transformation of one type of cell to another
Date: March 2017

It is also possible that other, unidentified, causative agents exist that result in the development of pleural mesothelioma such as certain chemicals, radiation, or viruses1

WHAT ARE THE RISK FACTORS FOR PLEURAL MESOTHELIOMA? Rating: 4.5 Diposkan Oleh: ABD KADIR Rusdi

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