The aim of this study was to gauge the effect of altered fractionation radiotherapy on mesothelioma. (Fractionation is the division of the total dose of radiation into small doses administered at intervals; radiation given in this manner usually causes less biological damage than the same total dose given at the same time.) Fifty-seven patients, 41 males and sixteen females, were treated with hemithorax irradiation with six different fractionation schedules. All were included in a combined modality program consisting of surgery followed by chemotherapy and finally by hemithorax irradiation.
The two-year survival rate of all patients was 21% and the five-year survival rate 9%. Two patients are still alive more than six and nine years after radiotherapy. Progression occurred after surgery in four patients, during and after chemotherapy in 22 patients and after completed radiotherapy in 29 patients. The pattern of progression was similar in each treatment group. Acta Oncologica, 36(4):397-405, 1997.
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