Wednesday, 27 December 2017

RETINOL CHEMO-PREVENTION


CHEMOTHERAPY

RETINOL CHEMO-PREVENTION. Former blue asbestos workers known to be at high risk of asbestos-related diseases, particularly malignant mesothelioma and lung cancer, were enrolled in a chemo-prevention program using vitamin A. The aim of the study was to compare rates of disease and death in subjects randomly assigned to beta-carotene or retinol. Subjects were assigned randomly to take 30 mg/day beta-carotene or retinol. Subjects were randomly assigned to take 30 mg/day beta-carotene (512 subjects) or 25,000 IU/day retinol (512 subjects) and followed-up through death and cancer registries over 5 years. Median follow-up time was 232 weeks. Four cases of lung cancer and 3 cases of mesothelioma were observed in subjects randomized to retinol and 6 cases of lung cancer and 12 cases of mesothelioma in subjects randomized to beta-carotene. Mesothelioma was the most common single cause of death in the study. The relative rate of mesothelioma for those on retinol compared with those on beta-carotene was 0.24. There was a higher rate of ischaemic heart disease mortality in the retinol group. The results confirm other findings of a lack of any benefit from administration of large doses of synthetic beta-carotene. The finding of significantly lower rates of mesothelioma among subjects assigned to retinol requires further investigation. "Vitamin A and cancer prevention II: a comparison of the effects of retinol and beta-carotene", de Klerk, et al., International Journal of Cancer, 75(3):362-7, January 30, 1998.


Former blue asbestos workers known to be at high risk of asbestos-related diseases, particularly malignant mesothelioma and lung cancer, were enrolled in a chemo-prevention program using vitamin A. The aim of the study was to compare rates of disease and death in subjects randomly assigned to beta-carotene or retinol. Subjects were assigned randomly to take 30 mg/day beta-carotene or retinol. Subjects were randomly assigned to take 30 mg/day beta-carotene (512 subjects) or 25,000 IU/day retinol (512 subjects) and followed-up through death and cancer registries over 5 years. Median follow-up time was 232 weeks. Four cases of lung cancer and 3 cases of mesothelioma were observed in subjects randomized to retinol and 6 cases of lung cancer and 12 cases of mesothelioma in subjects randomized to beta-carotene. Mesothelioma was the most common single cause of death in the study. The relative rate of mesothelioma for those on retinol compared with those on beta-carotene was 0.24. There was a higher rate of ischaemic heart disease mortality in the retinol group. The results confirm other findings of a lack of any benefit from administration of large doses of synthetic beta-carotene. The finding of significantly lower rates of mesothelioma among subjects assigned to retinol requires further investigation. "Vitamin A and cancer prevention II: a comparison of the effects of retinol and beta-carotene", de Klerk, et al., International Journal of Cancer, 75(3):362-7, January 30, 1998.

RETINOL CHEMO-PREVENTION Rating: 4.5 Diposkan Oleh: ABD KADIR Rusdi

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cancer (53) women (2)

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