Wednesday, 27 December 2017

COMPLETE REMISSION OF PERITONEAL MESOTHELIOMA WITH CHEMOTHERAPY IN JAPAN




COMPLETE REMISSION OF PERITONEAL MESOTHELIOMA WITH CHEMOTHERAPY IN JAPAN. A 71 year-old Japanese woman presented with a malignant abdominal mass and ascites (effusion and accumulation of serous fluid). The mass demonstrated widespread peritoneal dissemination, which therefore could not be resected surgically. Pathological findings suggested a malignant peritoneal mesothelioma. The patient showed remarkable response to combined chemotherapy with an accompanying intraperitoneal injection of cisplatin and etoposide and an intravenous injection of caffeine. However, owing to side effects, this regimen was discontinued. The patient was administered a combination drug of uracil and tegafur in addition to intraperitoneal injection of cisplatin as an outpatient. By the 223rd day after surgery, the tumor mass and ascites had completely disappeared according to computerized tomography scans. 


Chemotherapy was judged to have resulted in complete remission. Such marked response to chemotherapy is rare in an advanced malignant peritoneal mesothelioma. Eight months later, the tumor recurred in the pleura. Another regimen of cisplatin and CPT-11 was performed. However, this treatment proved ineffective. The patient subsequently died of respiratory failure due to the mesothelioma. "A case of malignant peritoneal mesothelioma showed complete remission with chemotherapy", Imada, et al., Japanese Journal of Clinical Oncology, 28(2):145-8, February 1998. A 71 year-old Japanese woman presented with a malignant abdominal mass and ascites (effusion and accumulation of serous fluid). The mass demonstrated widespread peritoneal dissemination, which therefore could not be resected surgically. Pathological findings suggested a malignant peritoneal mesothelioma. The patient showed remarkable response to combined chemotherapy with an accompanying intraperitoneal injection of cisplatin and etoposide and an intravenous injection of caffeine. However, owing to side effects, this regimen was discontinued.

The patient was administered a combination drug of uracil and tegafur in addition to intraperitoneal injection of cisplatin as an outpatient. By the 223rd day after surgery, the tumor mass and ascites had completely disappeared according to computerized tomography scans. Chemotherapy was judged to have resulted in complete remission. Such marked response to chemotherapy is rare in an advanced malignant peritoneal mesothelioma. Eight months later, the tumor recurred in the pleura. Another regimen of cisplatin and CPT-11 was performed. However, this treatment proved ineffective. The patient subsequently died of respiratory failure due to the mesothelioma. "A case of malignant peritoneal mesothelioma showed complete remission with chemotherapy", Imada, et al., Japanese Journal of Clinical Oncology, 28(2):145-8, February 1998.

COMPLETE REMISSION OF PERITONEAL MESOTHELIOMA WITH CHEMOTHERAPY IN JAPAN Rating: 4.5 Diposkan Oleh: ABD KADIR Rusdi

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