The antitumor effectiveness of cisplatin, paclitaxel and suramin as single agents and in combination was evaluated in vivo against four lines of human pleural malignant mesothelioma xenografts in mice. Cisplatin was very effective against one line and also to a lesser degree against another line. Paclitaxel showed antitumor effects similar to cisplatin, being very effective in one line, and also showed good activity in another line. Suramin was basically inactive in all four lines. Cisplatin and paclitaxel were combined and evaluated against the same four lines of mesothelioma, with a result of more pronounced antitumor effect in all four cell lines. These results indicate that the combination of cisplatin and paclitaxel is superior to each agent alone, and deserves to be evaluated in patients with malignant mesothelioma. "Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice", Chahinian, et al, Journal of Surgical Oncology, 67(2):104-11, February 1998.
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